- TPA 0.9 mg/kg up to a maximum of 90mg total.
- 10% given as IV bolus over 1 minute.
- Remaining 90% infused over 1 hour.
Note: Only TPA has been approved for the treatment of stroke.
Other drugs that may be given to patients with MI may not be used for stroke. These include reteplase (Retavase), tenecteplase (TNKase, Metalyse), streptokinase (Streptase).
Make sure to double-check the name of the drug because there are some hospitals that may not carry TPA. ED personnel may reach for one of the other thrombolytic drugs due to their comfort with them for use in acute myocardial infarction. Also, the dosing for stroke and acute myocardial infarction are different.
